Identifies EBV latent membrane protein-1, a cell surface-associated protein encoded by the EBV genome and expressed by a subset of EBV-infected B-cells, more commonly in tonsils than in lymph nodes of EBV-infected individuals. This antibody reacts strongly with EBV-positive lymphoblastoid cell lines and EBV infected B-cell immunoblasts in infectious mononucleosis, and also reacts with some EBV-associated neoplasms, particularly EBV-associated Hodgkin lymphoma. It is a much less sensitive marker than EBER.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.