This antibody reacts with an intermediate filament protein of both smooth and striated muscles, which is expressed primarily in skeletal, smooth, and cardiac muscle cells and tumors. It is useful in the identification of tumors of myogenic origin, reacting with leiomyosarcomas (smooth muscle) and rhabdomyosarcomas (striated muscle), and is also expressed in reactive mesothelium and angiomatoid fibrous histiocytoma.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.