Used to identify amyloid in tissue sections to demonstrate amyloidosis, a rare disease characterized by the deposition of insoluble misfolded proteins in various tissues and organs. The stain uses polarized light microscopy, and in cases with positive staining, immunohistochemical stains for amyloid A, amyloid P, and immunoglobulin light chains are available for further evaluation.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 10 micronsBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.NOTE: Clients should perform manual evaluation of the glass slide with polarized light for complete evaluation. Scanning at NeoGenomics is done with routine light microscopy.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.