A transmembrane protein that mediates phagocytosis by neutrophils and monocytes and is a marker of both benign and malignant follicular dendritic cells that can be used in addition to CD21, CD23, and podoplanin to identify follicular dendritic cells. It is also found on erthrocytes, B-clls, a subset of T-cells, monocytes, macrophages cultured in vitro, neutrophils, eosinophils, glomerular podocytes and follicular dendritic cells. It is also useful in the diagnosis of mucosa-associated lymphoid tissue lymphoma and in studying inflammatory disorders.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.