A cytoplasmic and cell surface-associated protein expressed by a significant subset of activated B cells and T cells and is a lymphocyte activation antigen related to tumor necrosis factor. It is strongly and uniformly expressed in anaplastic large cell lymphoma among non-Hodgkin lymphomas, and is expressed at variable levels in infectious mononucleosis, lymphocytes infected with HIV, HTLV-1, EBV, HHV8 or hepatitis B, Reed-Sternberg cells, lymphomatoid papulosis, peripheral T-cell lymphomas, the majority of cases of classical Hogkin lymphoma, and embryonal cell tumors.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.