A B cell specific surface antigen expressed in mature B cells, with expression restricted to normal and neoplastic B-cells, such as mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma, and absent from other hemopoietic cell types. It is highly expressed in hairy cell leukemia and follicular, mantle, and marginal zone B-cells. It is weakly expressed in germinal center B-cells.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.