A useful tumor marker for ovarian carcinomas because it reacts with most epithelial ovarian neoplasms of serous, endometrioid, clear cell, and undifferentiated types. It has also been described in other neoplasms such as seminal vesicle and anaplastic lymphomas. It also reacts with both normal tissues and neoplasms of fallopian tube, endometrium, endocervix, and mesothelioma, but does not react with mucinous ovarian tumors and colon cancer, and normal tissues such as breast, liver, skin, kidney, and spleen are negative.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.