Identifies an important regulator of cell-cell adhesion and embryogenesis, and mutations of this showing abnormal localization (cytoplasmic or nuclear staining) are characteristic of abdominal fibromatoses. High levels of nuclear expression can also be seen in endometrial stromal tumors, synovial sarcomas, solitary fibrous tumors, osteosarcoma, liposarcoma, palisaded myofibroblastoma, and a subset of colorectal and endometrial adenocarcinoma. Dysregulation of beta-catenin also occurs in Gardner syndrome, and leads to both familial adenomatous polyposis and fibromatosis.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.