Identifies a cytoplasmic protein ubiquitously expressed in T cells and NK cells, and in neoplasms derived from these cells. It is not expressed by most normal B cells, but is expressed in a variety of B cell non-Hodgkin lymphomas. Expression of ZAP-70 in chronic lymphocytic leukemia/small lymphocytic lymphoma strongly correlates with a lack in immunoglobulin gene mutation, and has been associated with an adverse prognosis.
• Formalin-fixed, paraffin-embedded (FFPE) tissue block or cell block - OR - • 3 unstained slides for each test requested plus 1-2 additional unstained slides cut at 4µm