Vimentin

Identifies vimentin, the primary intermediate filament protein in various mesenchymal cells, including endothelial cells, fibroblasts, macrophages, Sertoli cells, melanocytes, lymphocytes, and ovarian granulosa cells. Vimentin is expressed in most sarcomas and lymphomas and can be co-expressed with cytokeratin in some carcinomas, though lineage-specific markers like TTF-1 or PAX-8 are preferred in these cases. Strong positivity is seen in fibrosarcomas, liposarcomas, malignant fibrous histiocytomas, angiosarcomas, chondrosarcomas, melanomas, and Schwannomas.