Identifies a nuclear transcription factor found predominantly in lung and thyroid neoplasms. In lung carcinomas, it is expressed in both non-neuroendocrine as well as endocrine neoplasms, but only rarely in lung squamous cell carcinomas. It is expressed in all variants of thyroid carcinoma with the exception of anaplastic carcinoma. It can also be more uncommonly expressed in other carcinomas, including those primary to the colorectum and breast. The utility of this antibody becomes apparent in the differential diagnosis of primary versus metastatic carcinomas, especially in the lung.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.