TP53 Mutation Analysis

Bi-directional sequencing of TP53 exons 4-9.

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The TP53 gene encodes the tumor suppressor p53. TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. For patients with chronic lymphocytic leukemia (CLL), TP53 sequencing, in addition to FISH for 17p deletion, aids in prognosis and/or therapy selection. Germline mutations in TP53 are the cause of Li-Fraumeni Syndrome.