Identifies a cytoplasmic protein expressed in a coarse granular pattern in both cytotoxic T cells and NK cells, and on neoplasms arising from these cell types, including the majority of anaplastic large cell lymphomas. It also reacts with most granular lymphocytic leukemias, hepatosplenic T cell lymphomas, intestinal T cell lymphomas, NK-like T cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T cell lymphomas, and pulmonary angiocentric lymphomas of T or NK phenotype. All B cell lymphomas, Hodgkin, and lymphoblastic leukemias are negative for TIA1.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.