Identifies a member of the helix-loop-helix family of transcription factors, which is a sensitive and specific marker of Xp11 translocation in renal cell carcinomas. It is also expressed in alveolar soft part sarcoma, which is a chromosomal rearrangement at 17q25 and Xp11.2.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.