Identifies transcription factor proteins that are normally located in the cytoplasm in latent form and migrate to the nucleus on cytokine exposure and subsequent phosphorylation. Recurrent fusions between NAB2 and STAT6 in chromosome 12q13 have been present in the majority of solitary fibrous tumors/hemangiopericyomas. Nuclear STAT6 immunoreactivity has been reported as a surrogate marker for the NAB2-STAT6 gene fusion, and is used to identify solitary fibrous tumor as it is the defining driver of mutation for these tumors
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.