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Identifies STAT6, a transcription factor normally in the cytoplasm that translocates to the nucleus upon activation. Nuclear STAT6 immunoreactivity serves as a surrogate marker for NAB2-STAT6 gene fusions, which are characteristic of solitary fibrous tumors/hemangiopericytomas, aiding in their identification.
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred.
Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked.
Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.