Identifies a transcription factor expressed in almost all cases of mantle cell lymphoma (MCL) including cyclin D1-negative MCL. Routine use of anti-SOX11 in cases of suspected CD5+ diffuse large B cell lymphoma might help identify additional cases of cyclin D1-negative blastoid MCL. It is not expressed in potential MCL mimics such as atypical chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, and marginal zone lymphoma.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.