A highly specific and sensitive nuclear transcription factor found in nerve sheath tumors and melanomas, including conventional, spindled, and desmoplastic subtypes. It has also been expressed in salivary gland as well as soft tissue tumors showing myoepithelial differentiation, and is diffusely expressed in schwannoma, neurofibroma, and granular cell tumor. It was not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas. SOX10 is also far more specific than S100.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.