A novel cytoskeletal protein that reacts with proteins exclusively found in smooth muscle cells. Because it only reacts with smoothelin, which is exclusively found in smooth muscle cells, it aids in differentiating from cells with smooth muscle cell-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle cells. It could be used to differentiate muscularis propria from muscularis mucosa.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.