Identifies a component of smooth muscle myosin, a protein expressed in cells and tumors showing smooth muscle or myoepithelial differentiation. This antibody reacts with human visceral and vascular smooth muscle cells and myoepithelial cells and is useful in distinguishing between benign sclerosing breast leasons and infiltrating carcinomas because it strongly stains the myoepithelial layer in the benign lesions while being negative in the infiltrating carcinomas.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.