Smooth Muscle Actin (SMA)

Binds to smooth muscle cells and myoepithelial cells and stains the muscularis propria and muscularis mucosae of the GI tract, the uterine myometrium, medial layer of blood vessels, myoepithelial cells of salivary glands, and other organs. It does not stain skeletal and cardiac muscle, endothelium, connective tissue, epithelium, or nerve. It identifies leiomyomas, leiomyosarcomas, and mesenchymal tumors manifesting myofibroblastic differentiation.

Synonyms
Turnaround Time
24 hrs
Methodology
IHC
Specimen Requirements

A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

CPT Codes
88342 x 1 or 88341 x 1