Identifies a nuclear and cytoplasmic marker of a wide subset of tumors. The antibody to S100 protein stains Schwannomas, ependymomas, astrogliomas, almost all benign melanocytic lesions, melanomas, and their metastases.. The protein is also expressed in the Langerhans cells in the skin and interdigitating reticulum cells in the paracortex of lymph nodes.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.