Identifies a proto-oncogene highly expressed in a variety of tumor cells. Rearrangement of the ROS1 gene results in the production of constitutively active fusion proteins that have been reported in non-small cell lung cancers. ROS1 gene rearrangements are reported in 1% and 2% of lung adenocarcinomas and are associated with a response to the multi-targeted tyrosine kinase inhibitor crizotinib. Data suggests that ROS1-rearragned cancers respond to ALK inhibitors and the performance characteristics of this antibody justify its use as an alternative to, or in conjunction with, ROS1 FISH for the identification of lung adenocarcinomas harboring ROS1 gene translocations.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.