Identifies a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors. Because it may act by regulating transcription, loss of its function leads to uncontrolled cell growth. Aberrations of the RB gene are involved in cancers of the breast, colon, prostate, kidney, nasopharynx, and leukemia.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.