Identifies a 40kDa O-linked sialoglycoprotein expressed by a variety of tissues, including fetal testes and testicular germ cell tumors. Podoplanin is a marker of lymphatic endothelium, as well as neoplasms such as Kaposi's sarcoma. In the context of epithelial tumors, it has been demonstrated to be a highly sensitive marker of mesothelium and mesothelioma, complementing other markers such as calretinin and the Wilms tumor gene product. In neoplastic tissue, immunostaining of lymphatic endothelium can be useful in identifying lymphatic invasion of primary tumors.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.