Identifies a cell surface protein in the immunoglobulin superfamily that is a marker of follicular helper T (TFH) cells and is expressed on activated T cells, B cells, and myeloid cells. TFH cells are normally found in the germinal centers of benign lymphoid tissues, and are the putative cell of origin for some T cell non-Hodgkin lymphomas, including angioimmunoblastic T cell lymphomas, and because PD-1 is expressed by few B cells, it may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. Anti-PD-1 therapy represents a promising new therapy designed to enhance ability of the immune system to target and kill cancer cells.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with spe