Identifies a nuclear transcription factor that is a member of the paired box (PAX) family of transcription factors that is responsible for playing critical roles during fetal development and cancer growth. PAX8 is involved in kidney cell differentiation and thyroid development. It is expressed in three of the most common types of renal cell carcinoma, including clear cell, chromophobe, and papillary carcinoma. It is also a marker of carcinomas of the GYN tract (ovary, endometrium) and is expressed in thyroid carcinomas. It stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded (FFPE) tissues.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.