Identifies a B-cell specific activator protein (BSAP) expressed throughout B-cell maturation prior to the plasma cell stage. PAX-5 is strongly expressed in the great majority of mature and immature B-cell neoplasms and in nodular lymphocyte predominance Hodgkin's lymphoma. It is expressed at decreased intensity in classical Hodgkin's lymphoma, and is not expressed in the great majority of plasma cell neoplasms. It is very specific to B-cell lineage and does not stain T-cells.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.