Identifies a transcription factor essential for kidney development. In the kidneys of a normal adult, this protein expression is limited to the nuclei of collecting ducts and distal tubules (to a lesser extent). It is expressed in early kidney organogenesis as well as in Wilms' tumor and renal cell carcinoma, and can be useful in the diagnosis of renal cell carcinoma.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.