Identifies a homologue of the p53 gene that is necessary for normal breast and prostate development and is expressed in myoepithelial cells, squamous and transitional epithelial cells, and the basal layer of prostate and other epithelial tissues. Unlike other markers of myoepithelial cells and basal cells, p63 immunoreactivity is localized to the nucleus of cells. Identification of p63, or its absence, can be useful in identifying the presence of invasive carcinoma in breast and prostate, as well as the identification of squamous and transitional cell carcinomas.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.