Identifies a tyrosine kinase which binds to E-cadherin within the cell membrane and predominates in virtually all types of epithelia. When E-cadherin is absent, P120 Catenin moves to the cell cytoplasm; therefore, it is useful in the diagnostic distinction between lobular (cytoplasmic staining pattern) and ductal (membranous) breast neoplasia.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.'
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.