Identifies a nuclear transcription factor to the NK2 homebox gene, involved in neural morphogenesis as well as the development of neuroendocrine cells, such as those of pancreatic islet cells. the expression of NKX2.2 is a useful biomarker for distinguishing primitive neuroectodermal tumor/Ewing sarcoma (PNET/ES) from other small blue round cell tumors when used as a component of a panel of other tests.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.