Identifies an aspartic protease expressed at high levels by type II pneumocytes of the lung that has a specific function in normal alveolar epithelium and is proposed to play a role in the proteolytic processing of surfactant precursors. It is a highly sensitive and specific marker of pulmonary adenocarcinoma, although it can also be expressed in a subset of renal cell carcinomas and ovarian carcinomas.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.