Identifies a nuclear transcription factor that plays a key role in the regulation of skeletal muscle differentiation, with nuclear expression restricted to skeletal muscle tissue and a sensitive marker of myogenic differentiation. It strongly labels the nuclei of myoblasts in developing skeletal muscle tissue, whereas the majority of adult skeletal muscle is negative. It can be employed as a highly sensitive and specific marker of rhabdomyosarcoma.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.