Identifies the MUM1 gene product, a protein that is overexpressed in late plasma-cell-directed stages of B-cell differentiation. In hematolymphoid neoplasms, MUM1 is positive in multiple myelomas, lymphoplasmacytic lymphomas, Reed-Sternberg cells of Hodgkin lymphoma and in approximately 50% of diffuse large B-cell lymphomas. It is expressed at low levels in marginal zone lymphomas, follicular lymphomas, and B cell CLL/SLL, and it is negative on Burkitt's lymphoma. MUM1 appears to be a marker of prognostic value as it has been found that the expression of MUM1 is associated with the poor prognosis of patients with diffuse large B-cell lymphoma.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.