MDM2

This test detects MDM2 gene amplification for the diagnosis of certain adipocytic tumors, specifically well-differentiated liposarcomas, atypical lipomatous tumors, and dedifferentiated liposarcomas containing cytogenic alterations of the 12q13-15 region. Benign lipomas and lipocytic tumors as well as most other non-lipomatous sarcomas and mesenchymal neoplasms have been shown to be negative for MDM2 amplification, and this test aids in distinguishing lipomatous/dedifferentiated liposarcomas from nonlipocytic sarcomas and mesenchymal neoplasms. Amplifications are detected infrequently in other soft tissue sarcomas, and are not detected in benign lipomas.