Identifies a differentiation antigen that is expressed in melanocytes and is a sensitive and specific marker of melanoma. It recognizes a subcellular fraction found in melanosomes and is a useful addition to melanoma panels as it is specific for melanocytic lesions. Both HMB 45 and Melan A are co-expressed in the majority of melanomas, but MART1 is also a marker of sex cord-stromal and adrenal cortical tumors.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.