Identifies a cysteine-rich protein that plays a central and crucial role in hematopoietic development and is expressed in normal human germinal-center (GC) and GC-derived lymphomas. It is also expressed at high levels in endothelial cells, spleen, hematopoietic precursors, and a significant proportion of acute lymphoblastic and myeloid leukemias. In the setting of diffuse large B-cell lymphomas (DLBCLs), LMO2 has high sensitivity in differentiating between germinal center B-cell DLBCLs and non-germinal center B-cell DLBCLs. It is rarely expressed in mature T, NK, and plasma cell neoplasms and is absent from non-hematolymphoid tissues, except for endothelial cells.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.