Identifies Langerin, a protein encoded by the CD207 gene, which is a transmembrane cell surface receptor produced by Langerhans cells and Langerhans cell neoplasms. It is a highly selective marker for Langerhans cells and the lesional cells of Langerhans cell histiocytosis. Langerin protein expression has utility in differentiating Langerhans cell histiocytosis from other non-Langerhans cell histiocytic proliferations.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.