The antibody to the lambda light chain of immunoglobulin is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin lymphomas. Marked decreases in the ration of kappa-positive cells to lambda-positive cells in normal/polyclonal B cell and plasma cell populations indicate lambda light chain-restriction, which is conventionally used as a surrogate for clonality among B cell neoplasms, and therefore malignancy.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.