Identifies a nuclear protein expressed in proliferating (i.e. non-G0) cells. It is preferentially expressed during late G1, S, M, and G2 phases of the cell cycle, while cells in the G0 phase are negative. It is used as a quantitative marker of cell proliferation in tumors, where increased proliferative activity is associated with more aggressive tumor and decreased disease-free survival period.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.