Identifies a member of the type I acidic subfamily of keratins, expressed in various different human tissues. It labels ductal and glandular epithelia, prostatic epithelia, and non-keratinizing squamous epithelia. It is also useful in the diagnosis of breast and cervical carcinoma. Because CK19 is not expressed in hepatocytes, the antibody to CK19 is also useful in the distinction of liver metastasis from hepatocellular carcinomas. Published studies suggest that CK19 expression, along with expression of galectin-3 and HBME-1, is useful in differentiating papillary carcinomas of the thyroid from benign thyroid lesions.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.