This clone identifies IgG4 positive plasma cells, which are present in the pancreatic tissue from patients with autoimmune pancreatitis. Autoimmune pancreatitis typically produces an enlarged pancreas with the narrowing of the pancreatic duct, and can mimic carcinoma. IgG4 staining in patients with chronic alcoholic pancreatitis and pancreatic ductal adenocarcinoma was rarely observed, and IgG4-positive plasma cells are a useful marker for the tissue diagnosis of autoimmune pancreatitis.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.