Identifies carbamoyl phosphate synthetase 1, a mitochondrial protein present in hepatocytes and hepatocellular carcinoma. The antibody also recognizes other benign and malignant liver derived tumors such as hepatoblastoma and hepatic adenoma. It typically stains in a granular cytoplasmic pattern and is useful in distinguishing hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinomas to the liver. It is also useful in differentiating hepatoblastoma from other small round cell tumors. It is also expressed in a. subset of gastric carcinomas as well as "hepatoid" carcinomas of various organs.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.