Identifies a protein of the lectin family, cytoplasmic proteins that can be translocated into the nucleus, that is upregulated in thyroid carcinoma and can be employed as part of a panel of markers to assist in the distinction of thyroid carcinomas from adenomas. It is strongly and diffusely positive in papillary thyroid carcinomas, but weakly and focally positive in adenomas, and it is also a useful marker to differentiate benign from malignant thyroid neoplasms.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.