Identifies von Willebrand factor, which is synthesized by endothelial cells and stored in the Weibel-Palade granules. The Factor-VIII related antigen is one of the available immunohistochemical markers of endothelial cells and has also been demonstrated in platelets and megakaryocytes. IHC staining of this antigen is also useful for diagnosis of vascular neoplasms and for identification of vascular invasion by neoplasms.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.