ERG is a member of the ETS transcription factor gene family and is strongly overexpressed in endothelial cells and is a highly specific and sensitive marker of vascular neoplasms, and expression has been shown to be a highly specific marker for prostate cancer. ERG expression is lacking in a wide variety of normal epithelial tissues and tumors, therefore detection of ERG by IHC is a useful tool for diagnosing prostate cancer or determining prostatic origin.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.