A cell surface-associated protein expressed on subsets of peripheral blood mononuclear cells, NK active cells and activated T-cells, including so-called large granular lymphocytes, and neoplasms derived from these cells. Hematopoietic malignancies that are CD57 positive include a minority of T-lymphoblastic leukemias, roughly three quarters of the indolent T-cell large granular lymphocytic leukemias, and a small portion of NK-cell lymphomas. Identification of positive cells is also useful in positively identifying lymphocyte-predominant Hodgkin lymphoma.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.