Identifies a family of membrane glycoproteins expressed at variable levels in hematopoietic cells (human leukocytes, including lymphocytes, monocytes, and eosinophils) but is absent on normal and malignant non-hematopoietic tissues. Aberrant loss of CD45 is seen in a subset of precursor B-lymphoblastic leukemias, the majority of multiple myelomas, and in nearly all cases of classical Hodgkin's lymphoma on Reed-Sternberg cells and variants.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.