A cell surface glycoprotein that is expressed on all thymocytes, T-cells, cells of myeloid lineage, and all leukocytes except resting B lymphocytes. CD34 antibody can be used to identify T-cell lymphoma and a subset of B-cell lymphoma. Co-expression with CD20 is a feature of a subset of low-grade lymphomas, and expression in lymphomas is highly correlated with CD5; therefore, most T-cell malignancies and a group of small lymphocyte B-cell malignancies are often positive, while follicular lymphoma is rarely positive.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.