Expressed in normal cells on activated CD4/CD8+ T cells, granulocytes, lymphocytes, macrophages, and NK cells, while in diseased cells it is detected on acute myeloid leukemia M4 and M5, hairy cell leukemia, lymphoplasmacytic lymphoma, small lymphocytic lymphoma, splenic lymphoma, Langerhans cell histiocytosis, sinus histiocytosis, psoriatic skin lesions, and some follicular lymphomas.
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen typeorOne (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody orderedBlock and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.